Auyon J Ghosh, Brian D Hobbs, Jeong H Yun, Aabida Saferali, Matthew Moll, Zhonghui Xu, Robert P Chase, Jarrett Morrow, John Ziniti, Frank Sciurba, Lucas Barwick, Andrew H Limper, Kevin Flaherty, Gerard Criner, Kevin K Brown, Robert Wise, Fernando J Martinez, Daniel McGoldrick, Michael H Cho, Dawn L DeMeo, Edwin K Silverman, Peter J Castaldi, Craig P Hersh
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are characterized by shared exposures and clinical features, but distinct genetic and pathologic features exist. These features have not been well-studied using large-scale gene expression datasets. We hypothesized that there are divergent gene, pathway, and cellular signatures between COPD and IPF. METHODS: We performed RNA-sequencing on lung tissues from individuals with IPF (n = 231) and COPD (n = 377) compared to control (n = 267), defined as individuals with normal spirometry...
April 21, 2022: Respiratory Research